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Italian world-renowned dermatologist and aesthetic pioneer Dr. Rossana Castellana embarked on a mission to enhance skin health and well-being from a holistic approach. Her primary focus was to find a solution to combat the damaging effects of chemical peels. After numerous laboratory trials, PRX Derm Perfexion was born from her research, passion, and expertise. With over 7 million treatments performed by more than 40,000 aesthetic providers in 67 countries, Dr. Castellana created a product that stands in a class of its own and in her own words, “transcends countries, religions, and climates.”


With over 15 years of rigorous safety and efficacy testing through advanced clinical evaluations involving real patients, PRX Derm Perfexion has revolutionized the skincare industry. As the first and only non-invasive Topical Collagen Biostimulator™, PRX has carved out a new category with its innovative, internationally-patented formulation. This unique product stimulates collagen production by penetrating the skin without the need for needles. Inspired by the timeless elegance of Italian craftsmanship, PRX Derm Perfexion is the result of meticulous research and testing, offering a premium skincare line that seamlessly blends beauty with science, epitomizing luxury at its finest.


PRX Derm Perfexion is the only globally patented professional treatment formulated with 33% TCA and Hydrogen Peroxide that is clinically proven to deliver immediate and long-lasting results with no needles, no discomfort, and no downtime. 

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Medical advisory board

We've partnered with the industry's leading experts to bring you our PRX Visionaries. These professionals, at the forefront of medical innovation, are instrumental in showcasing the efficacy and safety of PRX Derm Perfexion. Through their advocacy and expertise, they play a vital role in building and sustaining the credibility of our brand.

Dr. Ava Shamban

Board-Certified Dermatologist 

Founder, AVA MD Dermatology (Beverly Hills & Santa Monica, CA) and SKIN FIVE (Pacific Palisades, CA)

Dr. Ava Shamban is a board-certified dermatologist. She is the founder of Ava MD Dermatology and SKIN FIVE. She also operates the Ava T. Shamban Research Clinic, where she leads FDA clinical trials as a principal investigator for prominent companies such as Allergan, Evolus, Merz, Galderma, and Revance.

Dr. Ava’s expertise and skill as a master injector and dermatologist have earned her the nickname “Dr. Pretty Pout” in Hollywood, and she is widely recognized as the go- to expert for cosmetic aesthetics.

In addition to her practices in Santa Monica and Beverly Hills, Dr. Ava was also an Assistant Clinical Professor of Dermatology at the UCLA-Geffen School of Medicine. She lectures internationally and serves as a principal investigator on many clinical and FDA trials. She is currently a member of the ASDS and the AAD; she also serves on the editorial board for The Journal of Clinical and Aesthetic Dermatology, among others.

She is the author of the best selling beauty book, Heal Your Skin: The Breakthrough Plan for Renewal (Wiley, 2011), and was a regular contributor on the Doctors and Extreme Makeover, as well as local and national news. She is a frequently sought after expert for health and beauty commentary and advice in top tier publications globally.

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Dr. Jeanine Downie

Board-Certified Dermatologist 

Founder, Image Dermatology (Montclair, NJ)

Jeanine B. Downie, M.D. is board certified by the American Board of Dermatology and holds medical licenses in the states of New Jersey, New York, and California. Dr. Downie is the director of her own practice, image Dermatology P.C. in Montclair, N.J. She has extensive training and experience in all aspects of dermatology, cosmetic dermatology, laser, and dermatologic surgery.

She is at the forefront of clinical trials for toxins, fillers, and cellulite. She specializes in clinical trials for unique medical breakthroughs, such as the Kybella fat melting injections. Because of that, her New Jersey office is often the go-to for clinical breakthroughs and trials.

Her work has brought a number of advances to the cosmetic dermatology industry and has made her a leading expert and resource for pharmaceutical developments.

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Dr. Jessie Cheung

Board-Certified Dermatologist

Founder, Cheung Aesthetics & Wellness (Willowbrook, IL & New York, NY)

Dr. Jessie Cheung is a board-certified, fellowship-trained dermatologist with practices in Chicago, Illinois and New York City. Her focus is on cosmetics, anti-aging and regenerative medicine, hormone replacement therapy, and sexual health.

Dr. Cheung is a speaker and trainer for threadlifts, fillers, biologic tissue products, and laser devices.

She has held faculty appointments at New York University Medical Center and Rush University Medical Center, and is now exclusively in private practice with an international clientele. She is also a member of several esteemed associations, including the American Society for Laser Medicine & Surgery.

She has been in practice for over 15 years, utilizing evidence-based treatments that have proven results for a full spectrum of skin colors, tones and types. Currently, Dr. Cheung is a key opinion leader (KOL), speaker, and trainer from Mint PDO threads, Miracu PDO threads, Radiesse, Sylfirm RF, and Fotona laser.

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Dr. Vivian Bucay

Board-Certified Dermatologist

Founder, Bucay Center for Dermatology and Aesthetics (San Antonio, TX)

Recognized nationally and internationally for her expertise in her combination approach in minimally invasive facial rejuvenation, Dr. Bucay is considered to be one of the pre-eminent dermatologists in the country.

Her credentials span a wide scope of biomedical research, patient care, and medical education. Passionate about skin wellness, Dr. Bucay has been featured as a skin expert in several publications, including Allure, Cosmetic Surgery Times, Elle, More, Shape, Prevention, New Beauty, Men’s Health and Good Housekeeping.

Since 2004, Dr. Bucay has been recognized yearly as a Texas Super Doctor by Texas Monthly Magazine. Dr. Bucay is a Distinguished Physician Member of the Liquid Face Lift Association and is the author or co-author of many publications and is involved in several studies evaluating emerging cosmeceuticals.

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PRX Derm Perfexion

PRX Derm Perfexion is a non-invasive Topical Collagen Biostimulator™ clinically proven to help tighten, tone, and lift the skin for visible rejuvenation of the face and body... experience the TTL Effect™ by WiQo®.

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Contact a PRX Derm Perfexion Provider today.

Discover more about the PRX Derm Perfexion treatment on this page or by scheduling a consultation with a PRX provider near you!